Structure and function of “metalloantibiotics”
- 14 August 2003
- journal article
- research article
- Published by Wiley in Medicinal Research Reviews
- Vol. 23 (6), 697-762
- https://doi.org/10.1002/med.10052
Abstract
Although most antibiotics do not need metal ions for their biological activities, there are a number of antibiotics that require metal ions to function properly, such as bleomycin (BLM), streptonigrin (SN), and bacitracin. The coordinated metal ions in these antibiotics play an important role in maintaining proper structure and/or function of these antibiotics. Removal of the metal ions from these antibiotics can cause changes in structure and/or function of these antibiotics. Similar to the case of “metalloproteins,” these antibiotics are dubbed “metalloantibiotics” which are the title subjects of this review. Metalloantibiotics can interact with several different kinds of biomolecules, including DNA, RNA, proteins, receptors, and lipids, rendering their unique and specific bioactivities. In addition to the microbial‐originated metalloantibiotics, many metalloantibiotic derivatives and metal complexes of synthetic ligands also show antibacterial, antiviral, and anti‐neoplastic activities which are also briefly discussed to provide a broad sense of the term “metalloantibiotics.” © 2003 Wiley Periodicals, Inc. Med Res Rev, 23 No. 6, 697–762, 2003Keywords
This publication has 695 references indexed in Scilit:
- Carbonic Anhydrase Inhibitors. Part 91. Metal Complexes of Heterocyclic Sulfonamides as Potential Pharmacological Agents in the Treatment of Gastric Acid Secretion ImbalancesMetal-Based Drugs, 2000
- A Theoretical-Experimental Study on the Structure and Activity of Certain Quinolones and the Interaction of Their Cu(II)-Complexes on a DNA ModelMetal-Based Drugs, 2000
- Biological Activity of Some Magnesium(II) Complexes of QuinolonesMetal-Based Drugs, 2000
- Structure Determination by Restrained Molecular Dynamics Using NMR Pseudocontact Shifts as Experimentally Determined ConstraintsJournal of the American Chemical Society, 1999
- A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicinBiochemical Pharmacology, 1999
- Hormone Anchored Metal Complexes. 1. Synthesis, Structure, Spectroscopy and In Vitro Antitumor Activity of Testosterone Acetate Thiosemicarbazone and its Metal ComplexesMetal-Based Drugs, 1999
- NMR Solution Structure of a DNA Dodecamer Duplex Containing a cis-Diammineplatinum(II) d(GpG) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug CisplatinBiochemistry, 1998
- Crystal structure of the Gramicidin/Potassium thiocyanate complexJournal of Molecular Biology, 1997
- Nuclear Magnetic Resonance Comparison of the Binding Sites of Mithramycin and Chromomycin on the Self-complementary Oligonucleotide d(ACCCGGGT)2Journal of Molecular Biology, 1993
- Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosidesJournal of Molecular Biology, 1987