Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides
- 1 February 1987
- journal article
- research article
- Published by Elsevier BV in Journal of Molecular Biology
- Vol. 193 (4), 661-671
- https://doi.org/10.1016/0022-2836(87)90349-4
Abstract
Methylation of either of two residues (G-1405 or A-1408) within bacterial 16 S ribosomal RNA results in high level resistance to specific combinations of aminoglycoside antibiotics. The product of a gene that originated in Micromonospora purpurea (an actinomycete that produces gentamicin) gives resistance to kanamycin plus gentamicin by converting residue G-1405 to 7-methylguanosine. Resistance to kanamycin plus apramycin results from conversion of residue A-1408 to 1-methyladenosine catalysed by the product of a gene from Streptomyces tenjimariensis.Keywords
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