Aromatic amino acid phosphoramidate di- and triesters of 3′-azido-3′-deoxythymidine (AZT) are non-toxic inhibitors of HIV-1 replication
- 17 August 1995
- journal article
- Published by Elsevier BV in Bioorganic & Medicinal Chemistry Letters
- Vol. 5 (16), 1819-1824
- https://doi.org/10.1016/0960-894x(95)00302-a
Abstract
No abstract availableKeywords
This publication has 17 references indexed in Scilit:
- Rational design for cytosolic delivery of nucleoside monphosphates : “SATE” and “DTE” as enzyme-labile transient phosphate protecting groupsBioorganic & Medicinal Chemistry Letters, 1993
- Intracellular delivery of nucleoside monophosphates through a reductase-mediated activation processAntiviral Research, 1993
- Differential phosphorylation of azidothymidine, dideoxycytidine, and dideoxyinosine in resting and activated peripheral blood mononuclear cells.JCI Insight, 1993
- Synthesis and anti-HIV evaluation of D4T and D4T 5'-monophosphate prodrugsJournal of Medicinal Chemistry, 1993
- Nucleoside Analogs: Similarities and DifferencesClinical Infectious Diseases, 1993
- O-Alkyl-5',5'-dinucleoside phosphates as prodrugs of 3'-azidothymidine and cordycepinThe Journal of Organic Chemistry, 1992
- Lipophilic glycosyl phosphotriester derivatives of AZT: synthesis, NMR transmembrane transport study and antiviral activityJournal of Medicinal Chemistry, 1991
- Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3'-azido-2'3'-dideoxythymidine (AZT) and other dideoxynucleoside congeners of thymidine.The Journal of Experimental Medicine, 1989
- Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages.The Journal of Experimental Medicine, 1987
- Biologically Reversible Phosphate-Protective GroupsJournal of Pharmaceutical Sciences, 1983