Elevated preoperative neutrophil to lymphocyte ratio predicts poor survival following resection in late stage gastric cancer
- 25 May 2011
- journal article
- research article
- Published by Wiley in Journal of Surgical Oncology
- Vol. 104 (5), 504-510
- https://doi.org/10.1002/jso.21986
Abstract
Background Elevated neutrophil to lymphocyte ratio (N/L ratio) has been shown to be a prognostic indicator in various cancers. We aimed to investigate the prognostic significance of the preoperative N/L ratio in late stage gastric cancer. Methods From April 2004 to August 2007, 293 patients who had undergone gastrectomy with curative intent for the AJCC/UICC TNM Stage III or IV gastric cancer were included. N/L ratio was calculated from lymphocyte and neutrophil counts on routine blood tests taken prior to surgery. Results The median follow-up time for surviving patients was 38.2 months (4.2–65.5 months) and median preoperative N/L ratio was 2.06 (range 0.47–19.73). Subjects were dichotomized at the N/L value of 2.0. A multivariate analysis established a significant relationship between the N/L ratio and overall survival (HR = 1.609; 95% confidence interval, CI, 1.144–2.264; P = 0.006). The cutoff value up to 3.0, the value of 75 percentiles, showed a significant prognostic effect on disease-free survival (HR = 1.654; 95% CI, 1.088–2.515; P = 0.019). Conclusions The results suggest that the elevated preoperative N/L ratio predicts poor disease-free and overall survival following resection for late stage gastric cancer. It may be utilized as a simple, reliable prognostic factor for risk stratification and will provide better treatment allocation. J. Surg. Oncol. 2011; 104:504–510.Keywords
Funding Information
- National Cancer Center (0720570)
- Chonnam National University Hospital Research Institute of Clinical Medicine (CRI11065-1)
This publication has 33 references indexed in Scilit:
- Circulating lymphocyte number has a positive association with tumor response in neoadjuvant chemoradiotherapy for advanced rectal cancerRadiation Oncology, 2010
- Elevated neutrophil to lymphocyte ratio predicts survival in advanced pancreatic cancerBiomarkers, 2010
- Pretreatment neutrophil count as an independent prognostic factor in advanced non-small-cell lung cancer: An analysis of Japan Multinational Trial Organisation LC00-03European Journal Of Cancer, 2009
- Impact of systemic inflammation on outcome following resection for intrahepatic cholangiocarcinomaJournal of Surgical Oncology, 2008
- Preoperative lymphocyte count as a prognostic factor in resected pancreatic ductal adenocarcinomaHPB, 2007
- The Baseline Ratio of Neutrophils to Lymphocytes Is Associated with Patient Prognosis in Advanced Gastric CancerOncology, 2007
- Vaccination of colorectal cancer patients with CEA-loaded dendritic cells: antigen-specific T cell responses in DTH skin testsAnnals Of Oncology, 2006
- Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancerJournal of Surgical Oncology, 2005
- Inflammation and cancerNature, 2002
- Significance of Increased Neutrophils in Patients with Advanced Colorectal CancerActa Oncologica, 1995