Antitubercular Activity of Disulfiram, an Antialcoholism Drug, against Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Isolates
- 1 August 2012
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 56 (8), 4140-4145
- https://doi.org/10.1128/aac.06445-11
Abstract
The antimycobacterial activities of disulfiram (DSF) and diethyldithiocarbamate (DDC) against multidrug- and extensively drug-resistant tuberculosis (MDR/XDR-TB) clinical isolates were evaluated in vitro . Both DSF and DDC exhibited potent antitubercular activities against 42 clinical isolates of M. tuberculosis , including MDR/XDR-TB strains. Moreover, DSF showed remarkable bactericidal activity ex vivo and in vivo . Therefore, DSF might be a drug repurposed for the treatment of MDR/XDR-TB.Keywords
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