Dithiocarbamates strongly inhibit the β-class carbonic anhydrases fromMycobacterium tuberculosis
- 6 December 2011
- journal article
- other
- Published by Informa UK Limited in Journal of Enzyme Inhibition and Medicinal Chemistry
- Vol. 28 (2), 407-411
- https://doi.org/10.3109/14756366.2011.641015
Abstract
A series of N-mono- and N,N-disubstituted dithiocarbamates have been investigated as inhibitors of two β-carbonic anhydrases (CAs, EC 4.2.1.1) from the bacterial pathogen Mycobacterium tuberculosis, mtCA 1 (Rv1284) and mtCA 3 (Rv3273). Both enzymes were inhibited with efficacies between the subnanomolar to the micromolar one, depending on the substitution pattern at the nitrogen atom from the dithiocarbamate zinc-binding group. Aryl, arylalkyl-, heterocyclic as well as aliphatic and amino acyl such moieties led to potent mtCA 1 and 3 inhibitors in both the N-mono- and N,N-disubstituted dithiocarbamate series. This new class of β-CA inhibitors may have the potential for developing antimycobacterial agents with a diverse mechanism of action compared to the clinically used drugs for which many strains exhibit multi-drug/extensive multi-drug resistance.Keywords
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