Caffeine and Miscarriage Risk
- 1 January 2008
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Epidemiology
- Vol. 19 (1), 55-62
- https://doi.org/10.1097/ede.0b013e31815c09b9
Abstract
Background: Coffee and caffeine have been inconsistently found to be associated with increased risk of clinical miscarriage—a poten- tially important association given the high prevalence of exposure. Methods: Women were recruited before or early in pregnancy and interviewed regarding sources of caffeine, including assessment of changes over the perinatal period. We identified 2407 clinically- recognized pregnancies resulting in 258 pregnancy losses. We ex- amined the relationship of coffee and caffeine intake with clinically- recognized pregnancy loss prior to 20 weeks' completed gestation, using a discrete-time continuation ratio logistic survival model. Results: Coffee and caffeine consumption at all 3 time points were unrelated to total miscarriage risk and the risk of loss after the interview. Reported exposure at the time of the interview was associated with increased risk among those with losses before the interview. Conclusions: There is little indication of possible harmful effects of caffeine on miscarriage risk within the range of coffee and caffeine consumption reported, with a suggested reporting bias among women with losses before the interview. The results may reflect exposure misclassification and unmeasured heterogeneity of preg- nancy losses. (Epidemiology 2008;19: 55- 62)Keywords
This publication has 22 references indexed in Scilit:
- Maternal Caffeine Consumption and Spontaneous AbortionEpidemiology, 2004
- Heterogeneity in Assessing Self-Reports of Caffeine ExposureEpidemiology, 2002
- Caffeine Intake and the Risk of First-Trimester Spontaneous AbortionNew England Journal of Medicine, 2000
- Maternal Caffeine Consumption and Spontaneous AbortionEpidemiology, 1996
- CAFFEINE AND SPONTANEOUS ABORTION OF KNOWN KARYOTYPEEpidemiology, 1991
- Caffeine Consumption during Pregnancy and Spontaneous AbortionEpidemiology, 1991
- EditorialEpidemiology, 1991
- Nausea and vomiting of early pregnancy and pregnancy outcome. A meta‐analytical reviewBJOG: An International Journal of Obstetrics and Gynaecology, 1989
- Nausea and Vomiting in Pregnancy – A Contribution to Its EpidemiologyGynecologic and Obstetric Investigation, 1983
- Passage of caffeine into human gonadal and fetal tissueBiochemical Pharmacology, 1962