Maternal Caffeine Consumption and Spontaneous Abortion
- 1 March 2004
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Epidemiology
- Vol. 15 (2), 229-239
- https://doi.org/10.1097/01.ede.0000112221.24237.0c
Abstract
Since the 1980s, numerous studies have investigated whether caffeine intake during pregnancy affects the risk of spontaneous abortion. A clear consensus, however, has not been reached. Because of the public health importance of this question, we reviewed the results of 15 epidemiologic studies on this topic, with particular attention to the specific methodologic problems that would generate biased findings. These include selection and recall bias, confounding, several issues pertaining to exposure measurement, and the failure to account for fetal karyotype, caffeine metabolism, the timing of fetal demise, and the possibility that an effect of caffeine may be gestational age-specific. All of the studies reviewed suffer from important methodologic limitations that hinder both the interpretation of each study individually and the comparison of results across studies. Despite the fact that most epidemiologic studies have observed a positive association between maternal caffeine intake and the risk of spontaneous abortion, we conclude that the evidence must be considered to be equivocal, given the biases likely present and the fact that most of the potential biases would tend to overestimate any association. Until studies can overcome these limitations, evidence for a causal link between caffeine and spontaneous abortion will remain inconclusive.Keywords
This publication has 49 references indexed in Scilit:
- Accuracy of self‐reported cigarette smoking among pregnant women in the 1990sPaediatric and Perinatal Epidemiology, 2001
- Smoking during pregnancy: how reliable are maternal self reports in New Zealand?Journal of Epidemiology and Community Health, 1997
- Risk Factors for Spontaneous Abortion: A Preliminary Study on Saudi WomenJournal of the Royal Society of Health, 1994
- Moderate caffeine use and the risk of spontaneous abortion and intrauterine growth retardationPublished by American Medical Association (AMA) ,1993
- EditorialEpidemiology, 1991
- Risk Factors for Spontaneous AbortionInternational Journal of Epidemiology, 1991
- Maternal and paternal moderate daily alcohol consumption and unexplained miscarriagesBJOG: An International Journal of Obstetrics and Gynaecology, 1990
- Nausea and vomiting of early pregnancy and pregnancy outcome. A meta‐analytical reviewBJOG: An International Journal of Obstetrics and Gynaecology, 1989
- Low fetal loss rates after ultrasound-proved viability in early pregnancyJAMA, 1987