Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women
- 9 November 2009
- journal article
- research article
- Published by Taylor & Francis Ltd in Gynecological Endocrinology
- Vol. 26 (4), 275-280
- https://doi.org/10.3109/09513590903366996
Abstract
Objective. The aim of this study was to compare the effectiveness of myo-inositol (MYO) and metformin, in monotherapy or in association with recombinant follicle stimulating hormone (r-FSH), in the treatment of menstrual irregularities, chronic anovulation, and female infertility in patients with polycystic ovary syndrome (PCOS). Materials and methods. One hundred twenty patients were randomly treated with metformin 1500 mg/day orally (n = 60), or 4 g MYO plus 400 μg folic acid daily (n = 60), continuously. If no pregnancy occurred, r-FSH (37.5 units/day) was added to the treatment for a maximum of three attempts. Results. Fifty percent of the patients who assumed metformin restored spontaneous ovulation, 18.3% of these obtained pregnancy. The remaining 42 patients were treated with metformin plus r-FSH. Pregnancy occurred in a total of 11 women (26.1%). The total pregnancy rate was 36.6%. Sixty-five percent of the patients treated with MYO plus folic acid restored spontaneous ovulation activity, 30% of these obtained pregnancy. The remaining 38 patients were treated with MYO, folic acid plus r-FSH. Pregnancy occurred in a total of 11 women (28.9%). The total pregnancy rate was 48.4%. Conclusions. Both metformin and MYO, can be considered as first line treatment for restoring normal menstrual cycles in most patients with PCOS, even if MYO treatment seems to be more effective than metformin.Keywords
This publication has 30 references indexed in Scilit:
- Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trialFertility and Sterility, 2009
- Insulin-stimulated release of d-chiro-inositol–containing inositolphosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovary syndromeMetabolism, 2008
- Metformin in the treatment of infertility in polycystic ovarian syndrome: an alternative perspectiveFertility and Sterility, 2008
- Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndromeGynecological Endocrinology, 2008
- Ovulation induction in polycystic ovary syndrome—how do metformin and clomifene citrate compare?Nature Clinical Practice Endocrinology & Metabolism, 2007
- Myo-inositol in patients with polycystic ovary syndrome: A novel method for ovulation inductionGynecological Endocrinology, 2007
- Altered D-Chiro-Inositol Urinary Clearance in Women With Polycystic Ovary SyndromeDiabetes Care, 2006
- Metformin in polycystic ovary syndrome: systematic review and meta-analysisBMJ, 2003
- Ovulatory and Metabolic Effects of d-Chiro-Inositol in the Polycystic Ovary SyndromeThe New England Journal of Medicine, 1999
- Second Messengers of Insulin ActionDiabetes Care, 1990