Subdivisions and derivatives of the chicken subpallium based on expression of LIM and other regulatory genes and markers of neuron subpopulations during development
- 22 May 2009
- journal article
- review article
- Published by Wiley in Journal of Comparative Neurology
- Vol. 515 (4), 465-501
- https://doi.org/10.1002/cne.22083
Abstract
Here we studied the combinatory expression patterns of nine developmental regulatory genes and six markers of different neuronal subpopulations in the telencephalic subpallium of developing chicken, from early embryos until hatching, in order to better understand the formation and organization of the basal telencephalon and the origin of its different cell groups. The genes analyzed include those encoding for: the transcription factors Islet1, Lhx6, Lhx7/8, Nkx2.1, and Pax6; the signaling protein Sonic hedgehog; the LIM‐only genes Lmo3 and Lmo4; the cell adhesion molecule cadherin‐8; markers of γ‐aminobutyric acid (GABA)ergic, cholinergic, or glutamatergic neurons; and markers of neuron subpopulations containing substance P, enkephalin, or neuropeptide Y. The combinatory expression patterns of these genes indicate that the chicken subpallium parcellates into eight molecularly different compartments during development (three striatal, three pallidal, and two preoptic subdivisions), and suggest that each compartment produces specific cell groups. Our data are particularly relevant for understanding the avian extended amygdala and suggest the existence of distinct central and medial extended amygdala complexes in the subpallium, as well as a pallial amygdalo‐hypothalamic cell corridor, which are comparable to homonymous complexes of mammals based on similar embryonic origin, molecular features, and some connectivity patterns. Our data also indicate that the dorsal and ventral parts of the chicken basal ganglia originate in different striatal and pallidal compartments, and suggest a massive migration of neurons from the pallidal compartment into the medial striatum, which may explain the existence of pallidal‐like cells within the medial striatum of birds. J. Comp. Neurol. 515:465–501, 2009.Keywords
This publication has 122 references indexed in Scilit:
- Anuran olfactory bulb organization: Embryology, neurochemistry and hodologyBrain Research Bulletin, 2008
- Convergence of olfactory and vomeronasal projections in the rat basal telencephalonJournal of Comparative Neurology, 2007
- Expanded expression of Sonic Hedgehog inAstyanaxcavefish:multiple consequences on forebrain development and evolutionDevelopment, 2007
- L3/Lhx8 is a pivotal factor for cholinergic differentiation of murine embryonic stem cellsCell Death & Differentiation, 2007
- Dopaminergic neurons intrinsic to the striatumJournal of Neurochemistry, 2007
- Nucleus accumbens subregions: hodological and immunohistochemical study in the domestic chick (Gallus domesticus)Cell and tissue research, 2006
- Organisation of the lamprey (Lampetra fluviatilis) embryonic brain: Insights from LIM-homeodomain, Pax and hedgehog genesDevelopmental Biology, 2005
- Avian brains and a new understanding of vertebrate brain evolutionNature Reviews Neuroscience, 2005
- Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explantsNature, 1995
- Heterogeneous development of calbindin‐D28K expression in the striatal matrixJournal of Comparative Neurology, 1992