Photodynamic Therapy in Oncology
Top Cited Papers
- 1 October 2006
- journal article
- review article
- Published by Oxford University Press (OUP) in The Oncologist
- Vol. 11 (9), 1034-1044
- https://doi.org/10.1634/theoncologist.11-9-1034
Abstract
Photodynamic therapy (PDT) is increasingly being recognized as an attractive, alternative treatment modality for superficial cancer. Treatment consists of two relatively simple procedures: the administration of a photosensitive drug and illumination of the tumor to activate the drug. Efficacy is high for small superficial tumors and, except for temporary skin photosensitization, there are no long-term side effects if appropriate protocols are followed. Healing occurs with little or no scarring and the procedure can be repeated without cumulative toxicity. Considering the efficacy and lack of long-term toxicity of PDT, and the fact that the first treatment of cancer with PDT was done more than 100 years ago, one might expect that this treatment had already become an established therapy. However, PDT is currently offered in only a few selected centers, although it is slowly gaining acceptance as an alternative to conventional cancer therapies. Here, we show the developmental steps PDT underwent and summarize the current clinical applications. The data show that, when properly used, PDT is an effective alternative treatment option in oncology.Keywords
This publication has 109 references indexed in Scilit:
- Carpe luz—seize the light: endoprevention of esophageal adenocarcinoma when using photodynamic therapy with porfimer sodiumGastrointestinal Endoscopy, 2005
- Photodynamic therapy with porfimer sodium for ablation of high-grade dysplasia in Barrett's esophagus: international, partially blinded, randomized phase III trialGastrointestinal Endoscopy, 2005
- Celecoxib and NS-398 Enhance Photodynamic Therapy by Increasing In vitro Apoptosis and Decreasing In vivo Inflammatory and Angiogenic FactorsCancer Research, 2005
- Choice of Oxygen-Conserving Treatment Regimen Determines the Inflammatory Response and Outcome of Photodynamic Therapy of TumorsCancer Research, 2004
- Photodynamic therapy for Barrett's esophagus with dysplasia and/or early stage carcinoma: long-term resultsGastrointestinal Endoscopy, 2003
- Phase II Trial of Debulking Surgery and Photodynamic Therapy for Disseminated Intraperitoneal TumorsAnnals of Surgical Oncology, 2001
- Role of the Immune System in Mediating the Antitumor Effect of Benzophenothiazine Photodynamic TherapyPhotochemistry and Photobiology, 1999
- Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's diseaseBritish Journal of Dermatology, 1996
- Changes in perfusion of mouse tumours after photodynamic therapyInternational Journal of Cancer, 1994
- THE EFFECTS OF THROMBOXANE INHIBITORS ON THE MICROVASCULAR AND TUMOR RESPONSE TO PHOTODYNAMIC THERAPYPhotochemistry and Photobiology, 1993