3′ Non-coding region sequences in eukaryotic messenger RNA
- 1 September 1976
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 263 (5574), 211-214
- https://doi.org/10.1038/263211a0
Abstract
The sequence A-A-U-A-A-A is present in six different purified messenger RNA molecules (specifically the alpha-and beta-globulin mRNAs of rabbit and human, the immunoglobulin light chain mRNA of mouse (MOPC 21) and the ovalbumin mRNA of chicken) about 20 residues away from the 3'-terminal poly (A) sequence. In addition, a large selection of the 3' non-coding regions of rabbit and human globulin mRNAs (both the alpha and beta globin mRNAs) are 85% homologous, demonstrating that this region is significantly conserved in evolutionKeywords
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