Allogenous Bone Grafts Improved by Bone Marrow Stem Cells and Platelet Growth Factors: Clinical Case Reports

Abstract

In order to increase the amount of available bone where dental implants must be placed, the present study has associated platelet-rich plasma (PRP) and mononuclear cells (MNCs) from bone marrow aspirate and bone scaffold (BS) in 32 patients aged between 45 and 75 years old. the MNC attainment and the adherence to the BS were confirmed through histology, cell culture, and scanning electron microscopy. the clinical results, analyzed by computed tomography, have showed that the scaffolds were well integrated and adapted to the cortical bone. We can conclude that the process of healing observed in the patients was due to the presence of mesenchymal stem cell in MNC fraction in the bone grafts.Universidade Federal de São Paulo, Dept Morfol Genet, Escola Paulista Med, BR-04023900 São Paulo, BrazilClin CERA LTDA, São Paulo, BrazilUniv São Paulo, Hosp Clin, Fac Med, BR-05508 São Paulo, BrazilUniv São Paulo, Inst Biociencias, Ctr Estudos Genoma Humano, BR-05508 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Morfol Genet, Escola Paulista Med, BR-04023900 São Paulo, BrazilWeb of Scienc