The phosphorylation of the integral membrane (M1) protein of influenza virus
- 30 April 1990
- journal article
- Published by Elsevier BV in Virus Research
- Vol. 16 (1), 27-41
- https://doi.org/10.1016/0168-1702(90)90041-9
Abstract
The phosphorylation of the internal and integral membrane (M1) protein of influenza virus was studied. Four points can be made based on the data: (1) The M1 contains at least two moles of phosphate per mole of M1. (2) Phosphorylation of M1 is conserved between influenza A, B and C viruses. Other characteristics of the M1 are also conserved, such as solubility in organic solvent, heterogeneity and ability to partition into lipid vesicles. (3) M1 is phosphorylated in cells infected with a vaccinia recombinant (vP273) containing only the gene of M1, either as a result of a vaccinia virus associated kinase or a cellular one. (4) The phosphate is located within or in close proximity to the major stretch of neutral and hydrophobic amino acids found in M1, as determined by analyzing cyanogen bromide fragments.Keywords
This publication has 33 references indexed in Scilit:
- Phosphorylation of tubulin enhances its interaction with membranesNature, 1986
- Recombinant Vaccinia Virus: Immunization Against Multiple PathogensScience, 1985
- Anomalous electrophoretic behavior of the membrane (M) protein of influenza virus in polyacrylamide gelsArchiv für die gesamte Virusforschung, 1983
- Nucleotide Sequence of Fowl Plague Virus RNA Segment 7Journal of General Virology, 1982
- Structure of the neuraminidase gene in human influenza virus A/PR/8/34Nature, 1981
- Avian sarcoma virus-transforming protein, pp60src shows protein kinase activity specific for tyrosineNature, 1980
- The Amino Acid and Carbohydrate Composition of the Neuraminidase of B/Lee/40 Influenza VirusJournal of General Virology, 1977
- Phosphorylation and dephosphorylation of membrane proteins as a possible mechanism for structural rearrangement of membrane componentsBiochimica et Biophysica Acta (BBA) - Biomembranes, 1976
- Further Investigation on the Fine Structure of Influenza VirusJournal of General Virology, 1972
- Phospholipid metabolism in the liver and lung of rats during developmentBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1965