Structure of the neuraminidase gene in human influenza virus A/PR/8/34
- 1 March 1981
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 290 (5803), 213-217
- https://doi.org/10.1038/290213a0
Abstract
The complete structure of the neuraminidase gene in influenza A/PR/8/34 has been determined by cloning into the bacteriophage M13 and sequencing with dideoxynucleotide chain terminators. The gene is 1,413 nucleotides long, codes for a protein of 454 amino acids and has five potential glycosylation sites. We suggest that the neuraminidase, unlike the influenza haemagglutinin, is oriented with its N-terminus buried in the viral membrane.Keywords
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