Cerebal norepinephrine depletion enhances recovery after brain ischemia
- 1 September 1985
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 18 (3), 329-336
- https://doi.org/10.1002/ana.410180310
Abstract
Monoamine neurotransmitters, especially norepinephrine (NE), may have an important role in the pathophysiological aspects of postischemic cerebral dysfunction. In previous studies of post-decapitation–induced ischemia, we found that NE depletion caused a delay in glycogen breakdown but did not influence any of the other known biochemical abnormalities that accompany brain ischemia. In this study, we have turned to a model of transient incomplete and diffuse forebrain ischemia in the rat to examine the effects of cerebral NE depletion on the recovery after brain ischemia of levels of high-energy phosphate compounds, products of intermediary oxidative metabolism, and free fatty acids. We found that a unilateral lesion of the locus ceruleus and the resultant depletion of NE in the ipsilateral cerebral cortex had no effect on sham-operated controls nor on rats subjected to ischemia alone. However, in rats subjected to ischemia followed by 15 minutes of recirculation, the NE-depleted cerebral cortex had significantly higher phosphocreatine and adenosine triphosphate levels and energy charge, and lower adenosine monophosphate and docosahexaenoic acid concentrations. With longer periods of recirculation, these side-to-side differences were not apparent. These results suggest that activity of the central NE systems during transient brain ischemia has deleterious effects on the biochemical recovery of the cerebral cortex from severe ischemic insults.This publication has 38 references indexed in Scilit:
- Free Fatty Acids and Energy Metabolites in Ischemic Cerebral Cortex with Noradrenaline DepletionJournal of Neurochemistry, 1984
- Brain Free Fatty Acids, Edema, and Mortality in Gerbils Subjected to Transient, Bilateral Ischemia, and Effect of Barbiturate AnesthesiaJournal of Neurochemistry, 1983
- Activation of Ethanolamine Phospholipase A2in Brain During IschemiaJournal of Neurochemistry, 1982
- Dopamine turnover estimated by simultaneous LCEC assay of dopamine and dopamine metabolitesJournal of Pharmacological Methods, 1982
- Cerebral Norepinephrine: Influence on Cortical Oxidative Metabolism in SituScience, 1979
- Transient cerebral ischemia and brain prostaglandinsBiochemical and Biophysical Research Communications, 1979
- Diffuse cerebral ischemia in the cat: II. Regional metabolites during severe ischemia and recirculationAnnals of Neurology, 1978
- EFFECT OF TRANSIENT ISCHEMIA ON MONOAMINE LEVELS IN THE CEREBRAL CORTEX OF GERBILS1,2Journal of Neurochemistry, 1978
- THE EFFECTS OF ALTERED ENDOCRINE STATES AND OF ETHER ANAESTHESIA ON MOUSE BRAIN1Journal of Neurochemistry, 1971
- Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brainBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1970