Transient cerebral ischemia and brain prostaglandins
- 1 February 1979
- journal article
- research article
- Published by Elsevier BV in Biochemical and Biophysical Research Communications
- Vol. 86 (3), 893-901
- https://doi.org/10.1016/0006-291x(79)91796-0
Abstract
Prostaglandin levels were measured in gerbil brain during cerebral ischemia for up to 2 hours, and during reperfusion after various periods of transient ischemia. The levels of PGF2α and its metabolite (13,14-dihydro-15-keto-PGF2α) were low and did not change during ischemia. However, PGF2α, 13,14-dihydro-15-keto-PGF2α, PGE2, and thromboxane B2 increased during reperfusion after brief episodes of ischemia. Indomethacin or aspirin inhibited this increase. Animals pretreated with indomethacin recovered more rapidly and were more active during reperfusion than those without treatment.This publication has 21 references indexed in Scilit:
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