Molecular basis of base substitution hotspots in Escherichia coli
- 1 August 1978
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 274 (5673), 775-780
- https://doi.org/10.1038/274775a0
Abstract
In the lacI gene of Escherichia coli spontaneous base substituion hotspots occur at 5-methylcytosine residues. The hotspots disappear when the respective cytosines are not methylated. We suggest that the hotspots may result from the spontaneous deamination of 5-methylcytosine to thymine, which is not excised by the enzyme DNA-uracil glycosidase.Keywords
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