ADH7 variation modulates extraversion and conscientiousness in substance‐dependent subjects
- 4 October 2007
- journal article
- research article
- Published by Wiley in American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics
- Vol. 147B (2), 179-186
- https://doi.org/10.1002/ajmg.b.30589
Abstract
Human personality traits have been closely linked to substance dependence (SD), and are partially genetically determined. Recently, associations between alcohol dehydrogenase 7 (ADH7 ) and SD have been reported, which led us to investigate the relationship between ADH7 variation and personality traits. We assessed dimensions of the five‐factor model of personality and genotyped 4 ADH7 markers and 38 unlinked ancestry‐informative markers in 244 subjects with SD [178 European‐Americans (EAs) and 66 African‐Americans (AAs)] and 293 healthy subjects (253 EAs and 40 AAs). The relationships between ADH7 markers and personality traits were comprehensively examined using multivariate analysis of covariance (MANCOVA), and then decomposed by Roy Bargmann Stepdown analysis of covariance (ANCOVA). Generally, older individuals, AAs, and males had significantly lower personality scores (4.7 × 10−5 ≤ P ≤ 0.032), as reported previously. In SD subjects, Extraversion was most significantly associated with ADH7 haplotypes (3.7 × 10−4 ≤ P ≤ 0.001), diplotypes (0.007 ≤ P ≤ 0.012), and genotypes (P = 0.001), followed by Conscientiousness (0.005 ≤ P ≤ 0.033). The contributory haplotype and diplotypes contained the alleles and genotypes of rs284786 (SNP1) and rs1154470 (SNP4). In healthy subjects, other personality factors (except Extraversion) were associated with ADH7 diplotypes (0.005 ≤ P ≤ 0.016) and genotypes (0.002 ≤ P ≤ 0.052). Some of the gene effects on personality factors were modified by sex. The present study demonstrated that the ADH7 variation may contribute to the genetic component of variation in personality traits, with the risk for SD and personality traits being partially shared.Keywords
This publication has 47 references indexed in Scilit:
- Personality Traits of Agreeableness and Extraversion are Associated with ADH4 VariationBiological Psychiatry, 2007
- Multiple ADH genes modulate risk for drug dependence in both African- and European-AmericansHuman Molecular Genetics, 2006
- Diplotype Trend Regression Analysis of the ADH Gene Cluster and the ALDH2 Gene: Multiple Significant Associations with Alcohol DependenceAmerican Journal of Human Genetics, 2006
- Detecting the number of clusters of individuals using the software structure: a simulation studyMolecular Ecology, 2005
- FAST‐TRACK: Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis)Molecular Ecology, 2004
- Upstream Structure of Human ADH7 Gene and the Organ Distribution of Its ExpressionBiochemical and Biophysical Research Communications, 1995
- The molecular and genetic dissection of the retinoid signalling pathwayGene, 1993
- Class IV alcohol dehydrogenase (the gastric enzyme) Structural analysis of human σσ‐ADH reveals class IV to be variable and confirms the presence of a fifth mammalian alcohol dehydrogenase classFEBS Letters, 1992
- Lack of alcohol dehydrogenase isoenzyme activities in the stomach of Japanese subjectsLife Sciences, 1991
- High Blood Alcohol Levels in WomenNew England Journal of Medicine, 1990