Ethyl Acetate Extract of the Stem Bark of Cudrania Tricuspidata Induces Apoptosis in Human Leukemia HL-60 Cells
- 1 January 2001
- journal article
- research article
- Published by World Scientific Pub Co Pte Ltd in The American Journal of Chinese Medicine
- Vol. 29 (02), 313-320
- https://doi.org/10.1142/s0192415x01000332
Abstract
Apoptosis is now widely accepted as playing a role in tumorigenesis. An effective compound which can kill tumors via apoptonic pathway appears to be a relevant strategy to suppress various human tumors. The ethyl acetate extract from the stem bark of Cudrania tricupidata (EACT) showed dose- and time-dependent cytotoxic effects on human leukemia HL-60 cells. DNA fragmentation and morphological changes, accompanied by condensed and fragmented nuclei, were observed in the cells cultured for 6 hr with EACT. These results suggest that the cytotoxicity of the crude extract from Cudrania tricuspidata against HL-60 cells is due to apoptosis.This publication has 14 references indexed in Scilit:
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