The Anti-inflammatory and Hepatoprotective Effects of Fractions from Cudrania cochinchinensis var. gerontogea
- 1 January 1999
- journal article
- research article
- Published by World Scientific Pub Co Pte Ltd in The American Journal of Chinese Medicine
- Vol. 27 (02), 227-239
- https://doi.org/10.1142/s0192415x99000264
Abstract
Various fractions of the ethanol extract from the root wood of Cudrania cochinchinensis var. gerontogea (Moraceae) were evaluated for their anti-inflammatory effects on carrageenan-induced edema and hepatoprotective activities on carbon tetrachloride (CCI4)-induced and D-galactosamine-(D-GalN) induced acute hepatotoxicity in rats. The fractions (n-hexane, CHCI3, EtOAc, n-BuOH, and H2O) displayed significant inhibitory activity against carrageenan-induced edema, and the active anti-inflammatory components were further localized in the n-BuOH fraction, which exhibited the greatest anti-inflammatory effect, an effect 5% greater than indomethacin (which was used as a standard reference substance). Each fraction exerted a significant hepatoprotective effect by reducing enzymatic alteration (sGOT and sGPT) and by improving hepatic lesions, including liver centrilobular inflammation, cell necrosis, fatty change, ballooning degeneration in CCl4-induced acute hepatitis; and necrosis of the portal area in D-GalN-induced acute liver injury. The n-BuOH and EtOAc fractions had the greatest hepatoprotective effects on CCl4)-induced liver injury; in contrast, the CHCI3) fraction was most potent against D-GalN intoxication, which is comparable to silymarin, as a recognized hepatoprotective drug.Keywords
This publication has 19 references indexed in Scilit:
- The antiinflammatory and liver protective effects ofBoussingaultia gracilis var.pseudobaselloides extract in ratsPhytotherapy Research, 1994
- Pharmacological studies on the crude drug ‘Hwang‐Jin‐Guey’ from Taiwan (1)Phytotherapy Research, 1994
- Archives of Toxicology, 1983
- Specificity of a phenobarbital-induced cytochrome P-450 for metabolism of carbon tetrachloride to the trichloromethyl radicalBiochemical Pharmacology, 1982
- d-Galactosamine hepatotoxicityExperimental and Molecular Pathology, 1978
- The induction of fibrillar nucleoli in rat liver cells by d-galactosamine and their subsequent re-formation into normal nucleoliJournal of Ultrastructure Research, 1973
- Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentineThe Journal of Pathology, 1971
- The Trapping of Uridine Phosphates by d‐Galactosamine, d‐Glucosamine, and 2‐Deoxy‐d‐galactoseEuropean Journal of Biochemistry, 1970
- Experimental hepatitis induced by d-galactosamineExperimental and Molecular Pathology, 1968
- The mechanism of the inflammatory effect of carrageeninEuropean Journal of Pharmacology, 1968