Giving Rise to Life: Transition from Prebiotic Chemistry to Protobiology
Top Cited Papers
- 21 March 2017
- journal article
- Published by American Chemical Society (ACS) in Accounts of Chemical Research
- Vol. 50 (3), 455-459
- https://doi.org/10.1021/acs.accounts.6b00470
Abstract
The challenge of a chemical approach to the origins of life problem involves comprehending the transition from prebiotic chemistry to protobiology. This endeavor demands demonstrating the metamorphosis of a diverse pool of prebiotic building blocks (heterogeneous heterogeneity) into a conglomerate self-assembling system (homogeneous heterogeneity) capable of evolution.Keywords
Funding Information
- Division of Chemistry (CHE-1504217)
- National Aeronautics and Space Administration
- Simons Foundation (327124)
This publication has 16 references indexed in Scilit:
- Ester-Mediated Amide Bond Formation Driven by Wet-Dry Cycles: A Possible Path to Polypeptides on the Prebiotic EarthAngewandte Chemie, 2015
- On the Emergence of RNAIsrael Journal of Chemistry, 2015
- Prebiotic Systems Chemistry: New Perspectives for the Origins of LifeChemical Reviews, 2013
- Prebiotically plausible oligoribonucleotide ligation facilitated by chemoselective acetylationNature Chemistry, 2013
- Functional RNAs exhibit tolerance for non-heritable 2′–5′ versus 3′–5′ backbone heterogeneityNature Chemistry, 2013
- Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneityProceedings of the National Academy of Sciences of the United States of America, 2011
- The Implausibility of Metabolic Cycles on the Prebiotic EarthPLoS Biology, 2008
- The roads to and from the RNA worldJournal of Theoretical Biology, 2003
- Chemical Etiology of Nucleic Acid StructureScience, 1999
- The origin of life—a review of facts and speculationsTrends in Biochemical Sciences, 1998