Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell
- 15 August 2000
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 97 (18), 10032-10037
- https://doi.org/10.1073/pnas.170209797
Abstract
We have discovered that intracellular redox state appears to be a necessary and sufficient modulator of the balance between self-renewal and differentiation in dividing oligodendrocyte-type-2 astrocyte progenitor cells. The intracellular redox state of freshly isolated progenitors allows prospective isolation of cells with different self-renewal characteristics. Redox state is itself modulated by cell-extrinsic signaling molecules that alter the balance between self-renewal and differentiation: growth factors that promote self-renewal cause progenitors to become more reduced, while signaling molecules that promote differentiation cause progenitors to become more oxidized. Moreover, pharmacological antagonists of the redox effects of these cell-extrinsic signaling molecules antagonize their effects on self-renewal and differentiation, indicating that cell-extrinsic signaling molecules that modulate this balance converge on redox modulation as a critical component of their effector mechanism.Keywords
This publication has 48 references indexed in Scilit:
- Redox Regulation of the Caspases during ApoptosisaAnnals of the New York Academy of Sciences, 1998
- Inhibition of p53-dependent apoptosis by the KIT tyrosine kinase: regulation of mitochondrial permeability transition and reactive oxygen species generationOncogene, 1998
- TGF-β1 Triggers Oxidative Modifications and Enhances Apoptosis in Hit Cells Through Accumulation of Reactive Oxygen Species by Suppression of Catalase and Glutathione PeroxidaseFree Radical Biology & Medicine, 1997
- Effects of Thyroid Hormone on Embryonic Oligodendrocyte Precursor Cell Developmentin Vivoandin VitroMolecular and Cellular Neuroscience, 1997
- Mechanism for the changes in levels of glutathione upon exposure of cultured mammalian cells to tertiary-butylhydroperoxide and diamideArchives of Toxicology, 1993
- Repair of demyelinated lesions by transplantation of purified 0-2A progenitor cellsNature, 1993
- Dihydrotetramethylrosamine: A long wavelength, fluorogenic peroxidase substrate evaluated in vitro and in a model phagocyteBiochemical and Biophysical Research Communications, 1991
- The Macroglial Cells of the Rat Optic NerveAnnual Review of Neuroscience, 1989
- A role for platelet-derived growth factor in normal gliogenesis in the central nervous systemCell, 1988
- A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture mediumNature, 1983