A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium
- 1 June 1983
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 303 (5916), 390-396
- https://doi.org/10.1038/303390a0
Abstract
We have identified a cell type in 7-day-old rat optic nerve that differentiates into a fibrous astrocyte if cultured in the presence of fetal calf serum and into an oligodendrocyte if cultured in the absence of serum. In certain culture conditions some of these cells acquire a mixed phenotype, displaying properties of both astrocytes and oligodendrocytes. These observations suggest that fibrous astrocytes and oligodendrocytes develop from a common progenitor cell and provide a striking example of developmental plasticity and environmental influence in the differentiation of CNS glial cells.Keywords
This publication has 30 references indexed in Scilit:
- Loss of axons from the optic nerve of the rat during early postnatal developmentDevelopmental Brain Research, 1982
- The loss of ganglion cells in the developing retina of the ratDevelopmental Brain Research, 1982
- Neural crest cell lineagesTrends in Neurosciences, 1981
- Biochemical studies of isolated glial (muller) cells from the turtle retinaThe Journal of cell biology, 1978
- Ultrastructural localization of glial fibrillary acidic protein in mouse cerebellum by immunoperoxidase labeling.The Journal of cell biology, 1977
- Binding of soluble form of fibroblast surface protein, fibronectin, to collagenInternational Journal of Cancer, 1977
- Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve I. Cell proliferationJournal of Comparative Neurology, 1976
- An electron microscopic study of the newt (Triturus viridescens) Optic NerveJournal of Comparative Neurology, 1974
- The neuroglia in the spinal cord of the newt,Triturus viridescensJournal of Comparative Neurology, 1969
- The Fixation of Tetanus Toxin, Strychnine, Serotonin and other Substances by GangliosideJournal of General Microbiology, 1963