STING-dependent signaling
- 20 September 2011
- journal article
- Published by Springer Science and Business Media LLC in Nature Immunology
- Vol. 12 (10), 929-930
- https://doi.org/10.1038/ni.2118
Abstract
The sensing of pathogen-associated DNA in the cytoplasm is an important trigger of host-defense responses that include the production of type I interferon. A new study suggests that the DExDc helicase DDX41 may function in dendritic cells as a DNA sensor to activate STING-dependent innate immune responses.Keywords
This publication has 12 references indexed in Scilit:
- The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cellsNature Immunology, 2011
- Pathogen Recognition by the Innate Immune SystemInternational Reviews of Immunology, 2011
- Type I Interferon Production Induced by RIG-I-Like ReceptorsJournal of Interferon & Cytokine Research, 2010
- IFI16 is an innate immune sensor for intracellular DNANature Immunology, 2010
- The InflammasomesCell, 2010
- RIGorous Detection: Exposing Virus Through RNA SensingScience, 2010
- STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunityNature, 2009
- STING is an endoplasmic reticulum adaptor that facilitates innate immune signallingNature, 2008
- DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune responseNature, 2007
- Antiviral innate immunity pathwaysCell Research, 2006