RIGorous Detection: Exposing Virus Through RNA Sensing
- 15 January 2010
- journal article
- perspective
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 327 (5963), 284-286
- https://doi.org/10.1126/science.1185068
Abstract
Virus infection in mammals elicits a variety of defense responses that are initiated by signals from virus-sensing receptors expressed by the host. These receptors include the ubiquitously expressed RIG-I–like receptor (RLR) family of RNA helicases. RLRs are cytoplasmic proteins that act in cell-intrinsic antiviral defense by recognizing RNAs indicative of virus presence. Here, we highlight recent progress in understanding how RLRs discriminate between the RNA content of healthy versus virus-infected cells, functioning as accurate sensors of virus invasion.Keywords
This publication has 19 references indexed in Scilit:
- RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I PathwayCell, 2009
- 5′-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-IProceedings of the National Academy of Sciences of the United States of America, 2009
- Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand VirusImmunity, 2009
- RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediateNature Immunology, 2009
- Agonist and Antagonist Recognition by RIG-I, a Cytoplasmic Innate Immunity ReceptorJournal of Biological Chemistry, 2009
- Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNANature, 2008
- Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5The Journal of Experimental Medicine, 2008
- Innate Recognition of VirusesImmunity, 2007
- Small self-RNA generated by RNase L amplifies antiviral innate immunityNature, 2007
- 5'-Triphosphate RNA Is the Ligand for RIG-IScience, 2006