Impact of liver steatosis on response to pegylated interferon therapy in patients with chronic hepatitis B
Open Access
- 1 January 2011
- journal article
- Published by Baishideng Publishing Group Inc. in World Journal of Gastroenterology
- Vol. 17 (40), 4517-22
- https://doi.org/10.3748/wjg.v17.i40.4517
Abstract
AIM: To evaluate the impact of liver steatosis upon response to given therapy in chronic hepatitis B (CHB) patients. METHODS: 84 consecutive CHB patients treated with 48-wk PEGylated interferon (PEG-IFN) therapy were enrolled. Baseline characteristics and sustained viral response (SVR) to PEG-IFN therapy were evaluated. RESULTS: Mean body mass index (BMI) was 27.36 ± 4.4 kg/m2. Six (7.1%) had hypertension and three (3.5%) had diabetes mellitus. Steatosis was present in 22.6% (19/84) of liver biopsy samples. Age, BMI, and triglyceride levels of the patients with hepatic steatosis were significantly higher than those without hepatic steatosis (P < 0.05). SVR to PEG-IFN therapy was 21.4% (18/84). Sixteen of these 18 CHB patients with SVR (88.9%) did not have any histopathologically determined steatosis. On the other hand, only two of the 19 CHB patients with hepatic steatosis had SVR (10.5%). Although the SVR rate observed in patients without steatosis (16/65, 24.6%) was higher compared to those with steatosis (2/19, 10.5%), the difference was not statistically significant (P > 0.05). CONCLUSION: Occurrence of hepatic steatosis is significantly high in CHB patients and this association leads to a trend of decreased, but statistically insignificant, SVR rates to PEG-IFN treatmentKeywords
This publication has 24 references indexed in Scilit:
- Hepatocellular Carcinoma and Non-Alcoholic Fatty Liver Disease: From a Clinical to a Molecular AssociationCurrent Pharmaceutical Design, 2010
- Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progressionGastroenterology, 2003
- Liver fibrosis is not associated with steatosis but with necroinflammation in French patients with chronic hepatitis CGut, 2003
- Steatosis accelerates fibrosis development over time in hepatitis C virus genotype 3 infected patientsJournal of Hepatology, 2002
- Histological comparison of chronic hepatitis B and C in an Indian population.2000
- Insulin regulation of regional free fatty acid metabolism.Diabetes, 1999
- Host- and disease-specific factors affecting steatosis in chronic hepatitis CJournal of Hepatology, 1998
- Sensitivity, specificity, and predictability of biopsy interpretations in chronic hepatitisGastroenterology, 1993
- Pathological diagnosis of chronic hepatitis C: A multicenter comparative study with chronic hepatitis BGastroenterology, 1993
- Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitisHepatology, 1981