Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
- 1 September 1981
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Hepatology
- Vol. 1 (5), 431-435
- https://doi.org/10.1002/hep.1840010511
Abstract
A Histology Activity Index has been developed which generates a numerical score for liver biopsy specimens obtained from patients with asymptomatic chronic active hepatitis. Biopsies are graded in four categories: periportal necrosis, intralobular necrosis, portal inflammation, and fibrosis. Under code, three pathologists and three hepatologists evaluated 14 liver biopsy specimens obtained from five patients with asymptomatic chronic active hepatitis. Good correlation was seen between severity of liver biopsy lesions as judged by conventional histological descriptions and Histology Activity Index scores. Significant differences in Histology Activity Index score occurred in only 2 of 28 duplicate scorings of biopsy specimens by two observers. This system provides definitive endpoints for statistical analysis of serial changes in liver histology and offers an alternative to the use of conventional pathological descriptions in following the natural history and treatment responses of asymptomatic chronic active hepatitis.This publication has 6 references indexed in Scilit:
- Liver biopsy in chronic hepatitis: 1968-78.Gut, 1978
- Development of Chronic Liver Disease after Acute Non-A, Non-B Post-Transfusion HepatitisGastroenterology, 1977
- Chronic active liver diseaseHuman Pathology, 1972
- Observer error and sampling variability tested in evaluation of hepatitis and cirrhosis by liver biopsyDigestive Diseases and Sciences, 1971
- Active chronic hepatitisAmerican Journal Of Medicine, 1970
- A CLASSIFICATION OF CHRONIC HEPATITISThe Lancet, 1968