What is a resistance gene? Ranking risk in resistomes
Top Cited Papers
- 15 December 2014
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Microbiology
- Vol. 13 (2), 116-123
- https://doi.org/10.1038/nrmicro3399
Abstract
Metagenomic studies have shown that antibiotic resistance genes are ubiquitous in the environment, which has led to the suggestion that there is a high risk that these genes will spread to bacteria that cause human infections. If this is true, estimating the real risk of dissemination of resistance genes from environmental reservoirs to human pathogens is therefore very difficult. In this Opinion article, we analyse the current definitions of antibiotic resistance and antibiotic resistance genes, and we describe the bottlenecks that affect the transfer of antibiotic resistance genes to human pathogens. We propose rules for estimating the risks associated with genes that are present in environmental resistomes by evaluating the likelihood of their introduction into human pathogens, and the consequences of such events for the treatment of infections.Keywords
This publication has 80 references indexed in Scilit:
- The Shared Antibiotic Resistome of Soil Bacteria and Human PathogensScience, 2012
- Identification of acquired antimicrobial resistance genesJournal of Antimicrobial Chemotherapy, 2012
- Overproduction of the multidrug efflux pump MexEF‐OprN does not impair Pseudomonas aeruginosa fitness in competition tests, but produces specific changes in bacterial regulatory networksEnvironmental Microbiology, 2012
- Genetic Determinants Involved in the Susceptibility of Pseudomonas aeruginosa to β-Lactam AntibioticsAntimicrobial Agents and Chemotherapy, 2010
- Novel Mechanism of Glycopeptide Resistance in the A40926 Producer Nonomuraea sp. ATCC 39727Antimicrobial Agents and Chemotherapy, 2010
- The role of natural environments in the evolution of resistance traits in pathogenic bacteriaProceedings. Biological sciences, 2009
- ARDB--Antibiotic Resistance Genes DatabaseNucleic Acids Research, 2008
- Evidence of Antibiotic Resistance Gene Silencing in Escherichia coliAntimicrobial Agents and Chemotherapy, 2006
- Multidrug-resistance efflux pumps ? not just for resistanceNature Reviews Microbiology, 2006
- Sampling the Antibiotic ResistomeScience, 2006