The prevalence and prevention of nasopharyngeal carcinoma in China
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Open Access
- 5 February 2011
- journal article
- review article
- Published by Editorial Office of Chinese Journal of Cancer in Chinese Journal of Cancer
- Vol. 30 (2), 114-119
- https://doi.org/10.5732/cjc.010.10377
Abstract
Nasopharyngeal carcinoma (NPC) has remarkable epidemiological features, including regional, racial, and familial aggregations. The aim of this review is to describe the epidemiological characteristics of NPC and to propose possible causes for the high incidence patterns in southern China. Since the etiology of NPC is not completely understood, approaches to primary prevention of NPC remain under consideration. This situation highlights the need to conduct secondary prevention, including improving rates of early detection, early diagnosis, and early treatment in NPC patients. Since the 1970's, high-risk populations in southern China have been screened extensively for early detection of NPC using anti–Epstein-Barr virus (EBV) serum biomarkers. This review summarizes several large screening studies that have been conducted in the high-incidence areas of China. Screening markers, high-risk age range for screening, time intervals for blood re-examination, and the effectiveness of these screening studies will be discussed. Conduction of prospective randomized controlled screening trials in southern China can be expected to maximize the cost-effectiveness of early NPC detection screening.Keywords
This publication has 36 references indexed in Scilit:
- Secular trends of nasopharyngeal carcinoma incidence in Singapore, Hong Kong and Los Angeles Chinese populations, 1973–1997European Journal of Epidemiology, 2007
- Trends in incidence and mortality of nasopharyngeal carcinoma over a 20–25 year period (1978/1983–2002) in Sihui and Cangwu counties in southern ChinaBMC Cancer, 2006
- Difference in the Incidence Trend of Nasopharyngeal and Oropharyngeal Carcinomas in Taiwan: Implication from Age-Period-Cohort AnalysisCancer Epidemiology, Biomarkers & Prevention, 2006
- Global Cancer Statistics, 2002CA: A Cancer Journal for Clinicians, 2005
- Has survival improved for nasopharyngeal carcinoma in the United States?Otolaryngology -- Head and Neck Surgery, 2005
- Changing epidemiology of nasopharyngeal carcinoma in Hong Kong over a 20‐year period (1980–99): An encouraging reduction in both incidence and mortalityInternational Journal of Cancer, 2002
- Cancer incidence trends in urban Shanghai, 1972-1994: An updateInternational Journal of Cancer, 1999
- Descriptive epidemiology and survival analysis of nasopharyngeal carcinoma in the united statesInternational Journal of Cancer, 1992
- Histopathologic types and incidence of malignant nasopharyngeal tumors in Zhongshan County.1983
- Demographic patterns for nasopharyngeal carcinoma in the united statesInternational Journal of Cancer, 1980