Postcricoid carcinoma: Is organ preservation justified in T3?
- 23 July 2014
- journal article
- research article
- Published by Wiley in The Laryngoscope
- Vol. 125 (2), 356-359
- https://doi.org/10.1002/lary.24846
Abstract
Introduction Postcricoid carcinoma in India, is seen especially in middle-aged females. Surgical treatment for postcricoid carcinoma has reduced because of increased organ-preserving nonsurgical strategies. Surgical intervention leads to morbidity in the form of laryngectomy. Objectives/Hypothesis To study the outcomes of nonsurgical management and to assess whether organ preservation is justified or if radical surgery should be the first line of management for T3 postcricoid carcinoma. Study Design/Methods This retrospective study analyzed 59 patients with T3 postcricoid carcinoma who were treated with nonsurgical modality in the form of radiotherapy (RT) or concurrent chemoradiotherapy (CCRT). End points studied were locoregional control, disease-free survival (DFS), and overall survival. We also observed feeding tube and tracheostomy tube dependency. Results Locoregional control rate, DFS rate, and overall survival at the end of 2 years were 8.98%, 8.59%, and 15.71% respectively. Seventeen and 12 patients of the study population were dependent on nasogastric tube and tracheostomy tube, respectively, until their last follow-up. Conclusion Results of organ preservation with radical RT or CCRT do not show promising outcomes in the locally advanced T3 carcinoma of postcricoid. Radical surgery with appropriate reconstruction and postoperative radiotherapy is probably better in terms of local control as well as overall survival. Proper preoperative counseling and postoperative rehabilitation of speech and stoma can improve the quality of life of T3 postcricoid carcinoma patients Level of Evidence 4. Laryngoscope, 125:356–359, 2015Keywords
This publication has 14 references indexed in Scilit:
- RECURRENT POST CRICOID WEB IN PLUMMER VINSON SYNDROME – IS IT MALIGNANCY NEXT?Journal of Evolution of Medical and Dental Sciences, 2013
- A clinical study of post-cricoid carcinomaActa Oto-Laryngologica, 2007
- Surgical treatment of squamous cell carcinoma of the hypopharynx: analysis of treatment results, failure patterns, and prognostic factorsThe Journal of Laryngology & Otology, 2004
- Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal CancerThe New England Journal of Medicine, 2003
- Health‐Related Quality of Life in Patients With Laryngeal Cancer: A Post‐Treatment Comparison of Different Modes of CommunicationThe Laryngoscope, 2001
- Organ Preservation by Transoral Laser Microsurgery in Piriform Sinus CarcinomaOtolaryngology -- Head and Neck Surgery, 2001
- Larynx Preservation in Pyriform Sinus Cancer: Preliminary Results of a European Organization for Research and Treatment of Cancer Phase III TrialJNCI Journal of the National Cancer Institute, 1996
- Squamous cell carcinoma of the pyriform sinus: A nonrandomized comparison of therapeutic modalities and long‐term resultsThe Laryngoscope, 1995
- Post‐cricoid cancer: An overviewSeminars in Surgical Oncology, 1989
- Carcinoma of the hypopharynxThe American Journal of Surgery, 1976