Enzyme-Linked Immunosorbent Assay for the Diagnosis of Melioidosis: Better Than We Thought
Open Access
- 1 April 2011
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 52 (8), 1024-1028
- https://doi.org/10.1093/cid/cir080
Abstract
We used Bayesian latent-class models to generate receiver operating characteristic curves and to revise the cutoff values for an enzyme-linked immosorbent assay that has been developed previously for melioidosis. The new cutoff was unbiased towards misclassification caused by an imperfect gold standard and resulted in an increase in both sensitivity (from 66.4% to 80.2%) and specificity (82.1% and 95.0%).Keywords
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