A complex Polycomb issue: the two faces of EZH2 in cancer
- 15 April 2012
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 26 (8), 751-755
- https://doi.org/10.1101/gad.191163.112
Abstract
In the April 1, 2012, issue of Genes & Development, Simon and colleagues (pp. 651–656) demonstrated that the disruption of Ezh2 in mice is sufficient to cause T-acute lymphoblastic leukemia (T-ALL). Moreover, in concert with concurrent studies, the authors revealed that similar mechanisms are involved in human T-ALL. These data contrast with previous findings showing that increased EZH2 activity promotes cancer.Keywords
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