Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells
Open Access
- 1 August 1985
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 316 (6030), 701-705
- https://doi.org/10.1038/316701a0
Abstract
The partial amino acid sequence of purified human transforming growth factor-.beta. (TGF-.beta.) was used to identify a series of c[complementary]DNA clones encoding the protein. The cDNA sequence indicates that the 112 amino acid monomeric form of the natural TGF-.beta. homodimer is derived proteolytically from a much longer precursor polypeptide which may be secreted. TGF-.beta. mRNA is synthesized in various normal and transformed cells.This publication has 49 references indexed in Scilit:
- Cloning and sequence analysis of a cDNA for rat transforming growth factor-αNature, 1985
- Human transforming growth factor-α: Precursor structure and expression in E. coliCell, 1984
- Rat Transforming Growth Factor Type 1: Structure and Relation to Epidermal Growth FactorScience, 1984
- Purification and properties of a type .beta. transforming growth factor from bovine kidneyBiochemistry, 1983
- Purification and initial characterization of a type beta transforming growth factor from human placenta.Proceedings of the National Academy of Sciences of the United States of America, 1983
- Polypeptide Transforming Growth Factors Isolated from Bovine Sources and Used for Wound Healing in VivoScience, 1983
- Serum contains a platelet-derived transforming growth factor.Proceedings of the National Academy of Sciences of the United States of America, 1982
- New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.Proceedings of the National Academy of Sciences of the United States of America, 1981
- Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.Proceedings of the National Academy of Sciences of the United States of America, 1980
- Transforming growth factors: isolation of polypeptides from virally and chemically transformed cells by acid/ethanol extraction.Proceedings of the National Academy of Sciences of the United States of America, 1980