Liver transplantation for HELLP syndrome
- 1 February 2005
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in Liver Transplantation
- Vol. 11 (2), 224-228
- https://doi.org/10.1002/lt.20285
Abstract
Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome is a rare complication of pregnancy that is associated with preeclampsia and may result in rupture of the liver. Although there have been case reports of liver transplantation for HELLP syndrome, the outcomes of transplantation for this rare indication have not been reported. Furthermore, the optimal management of complicated HELLP syndrome and indications for liver transplantation are unclear. Our objective was to review the national experience with liver transplantation for HELLP syndrome and to develop a comprehensive algorithm for the management of liver complications of HELLP syndrome, including indications for transplantation. A recent case from our institution is reported and the literature is reviewed. The results of liver transplantation for HELLP syndrome were analyzed from the United Network for Organ Sharing database. Between October 1987 and November 2003 there have been 8 deceased donor liver transplants performed for complications related to HELLP syndrome. As of the most recent follow‐up, 6 of the 8 patients are alive, with both deaths occurring within 1 month of transplantation, and 2 patients have required retransplantation. This review supports that good results can be obtained with liver transplantation for patients with complicated HELLP syndrome that have either ongoing, uncontrolled hemorrhage or liver necrosis and failure. Patients with complicated HELLP syndrome are best managed at a center with expertise in liver transplantation. (Liver Transpl 2005;11:224‐228.)Keywords
This publication has 17 references indexed in Scilit:
- Two-stage total hepatectomy and liver transplantation for acute deterioration of chronic liver disease: A new bridge to transplantationLiver Transplantation, 2004
- HELLP-Syndrom als Indikation für eine LebertransplantationGynäkologisch-geburtshilfliche Rundschau, 2001
- Die schwere Leberruptur beim HELLP-SyndromGeburtshilfe und Frauenheilkunde, 1997
- Liver Disease in PregnancyThe New England Journal of Medicine, 1996
- Spontaneous Hepatic Hemorrhage Associated with PregnancyAnnals of Surgery, 1996
- Liver transplant after massive spontaneous hepatic rupture in pregnancy complicated by preeclampsiaObstetrics & Gynecology, 1995
- Acute liver necrosis in the HELLP syndrome: successful outcome after orthotopic liver transplantation. A case reportTransplant International, 1993
- Auxiliary partial orthotopic liver transplantation (APOLT) for fulminant hepatic failure: First successful case reportWorld Journal of Surgery, 1991
- Hepatic Rupture in PregnancyObstetrical & Gynecological Survey, 1989
- RUPTURE OF THE LIVER ASSOCIATED WITH PREGNANCY: A REVIEW OF THE LITERATURE AND REPORT OF 2 CASESObstetrical & Gynecological Survey, 1976