Imaging the Impact of Prenatal Alcohol Exposure on the Structure of the Developing Human Brain
Open Access
- 3 March 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Neuropsychology Review
- Vol. 21 (2), 102-118
- https://doi.org/10.1007/s11065-011-9163-0
Abstract
Prenatal alcohol exposure has numerous effects on the developing brain, including damage to selective brain structure. We review structural magnetic resonance imaging (MRI) studies of brain abnormalities in subjects prenatally exposed to alcohol. The most common findings include reduced brain volume and malformations of the corpus callosum. Advanced methods have been able to detect shape, thickness and displacement changes throughout multiple brain regions. The teratogenic effects of alcohol appear to be widespread, affecting almost the entire brain. The only region that appears to be relatively spared is the occipital lobe. More recent studies have linked cognition to the underlying brain structure in alcohol-exposed subjects, and several report patterns in the severity of brain damage as it relates to facial dysmorphology or to extent of alcohol exposure. Future studies exploring relationships between brain structure, cognitive measures, dysmorphology, age, and other variables will be valuable for further comprehending the vast effects of prenatal alcohol exposure and for evaluating possible interventions.Keywords
This publication has 99 references indexed in Scilit:
- Memory and brain volume in adults prenatally exposed to alcoholBrain and Cognition, 2011
- Associations Between IQ, Total and Regional Brain Volumes, and Demography in a Large Normative Sample of Healthy Children and AdolescentsDevelopmental Neuropsychology, 2010
- Differentiating Prenatal Exposure to Methamphetamine and Alcohol versus Alcohol and Not Methamphetamine using Tensor-Based Brain Morphometry and Discriminant AnalysisJournal of Neuroscience, 2010
- Cingulate gyrus morphology in children and adolescents with fetal alcohol spectrum disordersPsychiatry Research: Neuroimaging, 2010
- Neurocognitive profile in children with fetal alcohol spectrum disordersDevelopmental Disabilities Research Reviews, 2009
- Volumetric MRI Study of Brain in Children With Intrauterine Exposure to Cocaine, Alcohol, Tobacco, and MarijuanaPEDIATRICS, 2008
- Occipital-temporal Reduction and Sustained Visual Attention Deficit in Prenatal Alcohol Exposed AdultsBrain Imaging and Behavior, 2007
- Abnormal Cortical Thickness and Brain-Behavior Correlation Patterns in Individuals with Heavy Prenatal Alcohol ExposureCerebral Cortex, 2007
- Longitudinal Brain Changes in Early-Onset PsychosisSchizophrenia Bulletin, 2007
- Fetal alcohol spectrum disorder: an overviewJournal of the Royal Society of Medicine, 2006