Associations Between IQ, Total and Regional Brain Volumes, and Demography in a Large Normative Sample of Healthy Children and Adolescents
- 3 May 2010
- journal article
- research article
- Published by Taylor & Francis Ltd in Developmental Neuropsychology
- Vol. 35 (3), 296-317
- https://doi.org/10.1080/87565641003696833
Abstract
In the course of efforts to establish quantitative norms for healthy brain development by magnetic resonance imaging (MRI) (Brain Development Cooperative Group, 2006), previously unreported associations of parental education and temporal and frontal lobe volumes with full scale IQ and its verbal and performance subscales were discovered. Our findings were derived from the largest, most representative MRI sample to date of healthy children and adolescents, ages 4 years 10 months to 18 years 4 months. We first find that parental education has a strong association with IQ in children that is not mediated by total or regional brain volumes. Second, we find that our observed correlations between temporal gray matter, temporal white matter and frontal white matter volumes with full scale IQ, between 0.14 to 0.27 in children and adolescents, are due in large part to their correlations with performance IQ and not verbal IQ. The volumes of other lobar gray and white matter, subcortical gray matter (thalamus, caudate nucleus, putamen, and globus pallidus), cerebellum, and brainstem do not contribute significantly to IQ variation. Third, we find that head circumference is an insufficient index of cerebral volume in typically developing older children and adolescents. The relations between total and regional brain volumes and IQ can best be discerned when additional variables known to be associated with IQ, especially parental education and other demographic measures, are considered concurrently.Keywords
This publication has 53 references indexed in Scilit:
- Positive association between cognitive ability and cortical thickness in a representative US sample of healthy 6 to 18 year-oldsIntelligence, 2009
- The Influence of Head Growth in Fetal Life, Infancy, and Childhood on Intelligence at the Ages of 4 and 8 YearsPEDIATRICS, 2006
- The association between brain volume and intelligence is of genetic originNature Neuroscience, 2002
- Mapping adolescent brain change reveals dynamic profile of accelerated gray matter loss in childhood-onset schizophreniaNeuroImage, 2001
- Variability of human brain structure size: ages 4–20 yearsPsychiatry Research: Neuroimaging, 1997
- Brain development, gender and IQ in childrenBrain, 1996
- Quantitative Magnetic Resonance Imaging of Human Brain Development: Ages 4–18Cerebral Cortex, 1996
- Head Circumference and Developmental Ability at the Age of Seven YearsActa Paediatrica, 1988
- A new look at the statistical model identificationIEEE Transactions on Automatic Control, 1974
- Intelligence, reading achievement, physical size, and social class: A study of St. Louis Caucasian boys aged 8-0 to 9–6 years, attending regular schoolsThe Journal of Pediatrics, 1974