The M235T polymorphism of the AGT gene modifies the risk of coronary artery disease associated with the presence of hypercholesterolemia
- 12 April 2008
- journal article
- Published by Springer Science and Business Media LLC in European Journal of Epidemiology
- Vol. 23 (5), 349-354
- https://doi.org/10.1007/s10654-008-9241-7
Abstract
Objective Atherosclerosis is an inflammatory disease resulting from interactions between various genetic and non-genetic factors. Angiotensinogen gene (AGT) belongs to polymorphic candidate genes. Recent evidence show that many traditional risk factors of coronary artery disease (CAD) influence synthesis of AGT. This report focuses on the interactions between M235T polymorphism of AGT gene and traditional risk factors of CAD. Material and Methods 255 subjects, including 158 patients with angiographically confirmed CAD and 97 blood donors without history of cardiovascular diseases were studied. M235T polymorphism of the AGT gene was genotyped using PCR-RFLP method. To determine the possible interactions of AGT genotypes and traditional risk factors of CAD the attributable proportion due to interaction (AP) and synergy models were used. Results The frequency of 235T allele carriers was significantly higher in patients than in controls (77.8 vs. 62.9, OR = 2.20, 95%CI; 1.10–4.40, P = 0.026, in multivariate logistic regression model). We found the existence of interaction between the 235T allele carrier-state and hypercholesterolemia (total cholesterol ≥5 mmol/l) increasing the risk of CAD (SI = 3.39, 95%CI; 1.33–8.66, AP = 0.65, 95%CI; 0.39–0.91). The 235T allele also interacted with elevated LDL cholesterol levels (≥3 mmol/l) (AP = 0.49, 95%CI; 0.20–0.96), but not with the hypertension, overweight/obesity and cigarette smoking. Conclusion The 235T allele increases the risk of CAD associated with the presence of hypercholesterolemia.Keywords
This publication has 33 references indexed in Scilit:
- Cross-talk between dyslipidemia and renin–angiotensin system and the role of LOX-1 and MAPK in atherogenesis: Studies with the combined use of rosuvastatin and candesartanAtherosclerosis, 2006
- Regulation of angiotensin-converting enzyme production by nicotine in human endothelial cellsAmerican Journal of Physiology-Heart and Circulatory Physiology, 2005
- Hypercholesterolemia Stimulates Angiotensin Peptide Synthesis and Contributes to Atherosclerosis Through the AT 1A ReceptorCirculation, 2004
- Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesityAmerican Journal of Physiology-Endocrinology and Metabolism, 2004
- European guidelines on cardiovascular disease prevention in clinical practiceThird Joint Task Force of European and other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of eight societies and by invited experts)Atherosclerosis, 2004
- Superoxide Generation in Directional Coronary Atherectomy Specimens of Patients With Angina PectorisArteriosclerosis, Thrombosis, and Vascular Biology, 2002
- Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulationThe FASEB Journal, 2001
- Myocardial infarction redefined—a consensus document of The Joint European Society of Cardiology/American College of Cardiology committee for the redefinition of myocardial infarction: The Joint European Society of Cardiology/ American College of Cardiology CommitteeJournal of the American College of Cardiology, 2000
- Confidence Intervals for Measures of InteractionEpidemiology, 1996
- Molecular basis of human hypertension: Role of angiotensinogenCell, 1992