Aptamer-Modified Nanodrug Delivery Systems
- 25 October 2011
- journal article
- review article
- Published by American Chemical Society (ACS) in ACS Nano
- Vol. 5 (10), 7696-7699
- https://doi.org/10.1021/nn2037384
Abstract
Aptamers can bind a wide range of biomedically relevant proteins with affinities and specificities that have therapeutic utility. Although aptamers are susceptible to nuclease-mediated degradation and cannot easily cross biological barriers, specific aptamer modification can feasibly solve these problems. To address these obstacles, Lau et al. developed a general strategy for generating natural packaging and transport vehicles for targeting agents, such as aptamers and their small-molecule ligands, by using virus-like particles (VLPs) assembled from the recombinant expression of the bacteriophage Qβ coat protein. Since RNA and DNA molecules are susceptible to nuclease-mediated degradation, it is important that Qβ VLPs protect their encapsulated aptamers from nuclease-mediated degradation and enhance their permeability. Moreover, if self-assembled using natural proteins, VLPs can guarantee the biocompatibility and biodegradability of modified aptamers in therapeutic applications. Therefore, this Perspective explores the outlook for such aptamer modification strategies for nanodrug preparation and delivery applications and the challenges that lie ahead.This publication has 23 references indexed in Scilit:
- Evolution and Protein Packaging of Small-Molecule RNA AptamersACS Nano, 2011
- Protein‐Based Nanomedicine Platforms for Drug DeliverySmall, 2009
- Carbon Nanotubes Protect DNA Strands during Cellular DeliveryACS Nano, 2008
- Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticlesJournal of Controlled Release, 2008
- Molecular assembly for high-performance bivalent nucleic acid inhibitorProceedings of the National Academy of Sciences of the United States of America, 2008
- Quantum Dot−Aptamer Conjugates for Synchronous Cancer Imaging, Therapy, and Sensing of Drug Delivery Based on Bi-Fluorescence Resonance Energy TransferNano Letters, 2007
- A model describing the effect of enzymatic degradation on drug release from collagen minirodsEuropean Journal of Pharmaceutics and Biopharmaceutics, 2007
- Targeting of Cancer Cells with Ferrimagnetic Ferritin Cage NanoparticlesJournal of the American Chemical Society, 2006
- Blue Fluorescent Antibodies as Reporters of Steric Accessibility in Virus ConjugatesBioconjugate Chemistry, 2002
- Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA PolymeraseScience, 1990