Protein‐Based Nanomedicine Platforms for Drug Delivery
- 31 July 2009
- Vol. 5 (15), 1706-1721
- https://doi.org/10.1002/smll.200801602
Abstract
Protein‐based nanomedicine platforms for drug delivery comprise naturally self‐assembled protein subunits of the same protein or a combination of proteins making up a complete system. They are ideal for drug‐delivery platforms due to their biocompatibility and biodegradability coupled with low toxicity. A variety of proteins have been used and characterized for drug‐delivery systems, including the ferritin/apoferritin protein cage, plant‐derived viral capsids, the small Heat shock protein (sHsp) cage, albumin, soy and whey protein, collagen, and gelatin. There are many different types and shapes that have been prepared to deliver drug molecules using protein‐based platforms, including various protein cages, microspheres, nanoparticles, hydrogels, films, minirods, and minipellets. The protein cage is the most newly developed biomaterial for drug delivery and therapeutic applications. The uniform size, multifunctionality, and biodegradability push it to the frontier of drug delivery. In this Review, the recent strategic development of drug delivery is discussed with emphasis on polymer‐based, especially protein‐based, nanomedicine platforms for drug delivery. The advantages and disadvantages are also discussed for each type of protein‐based drug‐delivery system.Keywords
This publication has 124 references indexed in Scilit:
- Tumour-targeted nanomedicines: principles and practiceBritish Journal of Cancer, 2008
- Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticlesJournal of Controlled Release, 2008
- Apoferritin-Templated Synthesis of Encoded Metallic Phosphate Nanoparticle TagsAnalytical Chemistry, 2007
- Bio-distribution, toxicity and pathology of cowpea mosaic virus nanoparticles in vivoJournal of Controlled Release, 2007
- Characterization of radioligand binding to a transmembrane receptor reconstituted into LipobeadsFEBS Letters, 2004
- Blue Fluorescent Antibodies as Reporters of Steric Accessibility in Virus ConjugatesBioconjugate Chemistry, 2002
- Small heat-shock protein structures reveal a continuum from symmetric to variable assembliesJournal of Molecular Biology, 2000
- Preferential Distribution of the Fluorescent Phospholipid Probes NBD-Phosphatidylcholine and Rhodamine-Phosphatidylethanolamine in the Exofacial Leaflet of Acetylcholine Receptor-Rich Membranes from Torpedo marmorataBiochemistry, 1995
- Size distribution of liposomes by flow field-flow fractionationJournal of Pharmaceutical and Biomedical Analysis, 1993
- Diffusion of univalent ions across the lamellae of swollen phospholipidsJournal of Molecular Biology, 1965