The Role of Inflammation in Age-Related Sarcopenia
Top Cited Papers
Open Access
- 12 December 2017
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Physiology
- Vol. 8, 1045
- https://doi.org/10.3389/fphys.2017.01045
Abstract
Many physiological changes occur with aging. These changes often, directly or indirectly, result in a deterioration of the quality of life and even in a shortening of life expectancy. Besides increased levels of reactive oxygen species, DNA damage and cell apoptosis, another important factor affecting the aging process involves a systemic chronic low-grade inflammation. This condition has already been shown to be interrelated with several (sub)clinical conditions, such as insulin resistance, atherosclerosis and Alzheimer's disease. Recent evidence, however, shows that chronic low-grade inflammation also contributes to the loss of muscle mass, strength and functionality, referred to as sarcopenia, as it affects both muscle protein breakdown and synthesis through several signaling pathways. Classic interventions to counteract age-related muscle wasting mainly focus on resistance training and/or protein supplementation to overcome the anabolic inflexibility from which elderly suffer. Although the elderly benefit from these classic interventions, the therapeutic potential of anti-inflammatory strategies is of great interest, as these might add up to/support the anabolic effect of resistance exercise and/or protein supplementation. In this review, the molecular interaction between inflammation, anabolic sensitivity and muscle protein metabolism in sarcopenic elderly will be addressed.Keywords
This publication has 161 references indexed in Scilit:
- Autophagy as a new therapeutic target in Duchenne muscular dystrophyCell Death & Disease, 2012
- Molecular and cellular mechanisms of skeletal muscle atrophy: an updateJournal of Cachexia, Sarcopenia and Muscle, 2012
- Role and potential mechanisms of anabolic resistance in sarcopeniaJournal of Cachexia, Sarcopenia and Muscle, 2012
- mTOR Signaling in Growth Control and DiseaseCell, 2012
- Ryanodine Receptor Oxidation Causes Intracellular Calcium Leak and Muscle Weakness in AgingCell Metabolism, 2011
- Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome PathwayPublished by Elsevier BV ,2010
- Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exerciseExperimental Gerontology, 2010
- Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscleMechanisms of Ageing and Development, 2008
- Effect of amino acid supplementation on muscle mass, strength and physical function in elderlyClinical Nutrition, 2008
- Apoptosis: A Review of Programmed Cell DeathToxicologic Pathology, 2007