Molecular pathways in pancreatic carcinogenesis
- 17 July 2012
- journal article
- review article
- Published by Wiley in Journal of Surgical Oncology
- Vol. 107 (1), 8-14
- https://doi.org/10.1002/jso.23213
Abstract
Pancreatic cancer is a genetic disease. Pancreatic cancers develop from one of three precursor lesions, pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasms (IPMNs), and mucinous cystic neoplasms (MCNs), and each arises in association with distinct genetic alterations. These alterations not only provide insight into the fundamental origins of pancreatic cancer but provide ample opportunity for improving early diagnosis and management of cystic precursors. J. Surg. Oncol. 2013;107:8–14.Keywords
Funding Information
- National Institutes of Health (CA140599, CA101955, CA62924)
This publication has 64 references indexed in Scilit:
- Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial NeoplasiaGastroenterology, 2012
- Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathwaysProceedings of the National Academy of Sciences, 2011
- Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreasScientific Reports, 2011
- Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor typesHuman Mutation, 2011
- Cystic precursors to invasive pancreatic cancerNature Reviews Gastroenterology & Hepatology, 2011
- Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancerProceedings of the National Academy of Sciences, 2011
- Distant metastasis occurs late during the genetic evolution of pancreatic cancerNature, 2010
- Regulation of Wnt/β‐catenin signaling by protein kinasesDevelopmental Dynamics, 2009
- BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreasCancer Letters, 2007
- Cancer genes and the pathways they controlNature Medicine, 2004