Direct Catalytic Asymmetric Mannich-Type Reaction of β-Keto Phosphonate Using a Dinuclear Ni2−Schiff Base Complex
- 9 July 2008
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 10 (15), 3239-3242
- https://doi.org/10.1021/ol800965t
Abstract
Direct catalytic asymmetric Mannich-type reactions of beta-keto phosphonates are described. A homodinuclear Ni 2-Schiff base complex promoted the reaction at 0 degrees C, giving beta-amino phosphonates in up to 90% yield, 20:1 dr, and 99% ee. Control experiments suggested that two Ni metals are important for achieving high yield and stereoselectivity.Keywords
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