Catalytic Asymmetric Synthesis of α-Amino Phosphonates Using Enantioselective Carbon−Carbon Bond-Forming Reactions
- 7 May 2004
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (21), 6558-6559
- https://doi.org/10.1021/ja048791i
Abstract
We have developed highly enantioselelctive reactions of silicon enolates with N-acyl-alpha-iminophosphonates leading to optically active alpha-amino phophonates. A copper (II)-diamine complex was shown to be effective in this reaction, and high levels of yield and selectivity were achieved. It is noteworthy that this reaction opens a way to various biologically important, optically active alpha-amino phosphonate derivatives.This publication has 16 references indexed in Scilit:
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