Cigarette Smoke, Bacteria, Mold, Microbial Toxins, and Chronic Lung Inflammation
Open Access
- 9 July 2011
- journal article
- review article
- Published by Hindawi Limited in Journal of Oncology
- Vol. 2011, 1-13
- https://doi.org/10.1155/2011/819129
Abstract
Chronic inflammation associated with cigarette smoke fosters malignant transformation and tumor cell proliferation and promotes certain nonneoplastic pulmonary diseases. The question arises as to whether chronic inflammation and/or colonization of the airway can be attributed, at least in part, to tobacco-associated microbes (bacteria, fungi, and spores) and/or microbial toxins (endotoxins and mycotoxins) in tobacco. To address this question, a literature search of documents in various databases was performed. The databases included PubMed, Legacy Tobacco Documents Library, and US Patents. This investigation documents that tobacco companies have identified and quantified bacteria, fungi, and microbial toxins at harvest, throughout fermentation, and during storage. Also characterized was the microbial flora of diverse smoking and smokeless tobacco articles. Evidence-based health concerns expressed in investigations of microbes and microbial toxins in cigarettes, cigarette smoke, and smokeless tobacco products are reasonable; they warrant review by regulatory authorities and, if necessary, additional investigation to address scientific gaps.Keywords
This publication has 64 references indexed in Scilit:
- Do changes in cigarette design influence the rise in adenocarcinoma of the lung?Cancer Causes & Control, 2010
- Different regulation of cigarette smoke induced inflammation in upper versus lower airwaysRespiratory Research, 2010
- Nonresolving InflammationCell, 2010
- Pattern Recognition Receptors and InflammationCell, 2010
- Collagen V-induced nasal tolerance downregulates pulmonary collagen mRNA gene and TGF-beta expression in experimental systemic sclerosisRespiratory Research, 2010
- Abuse Liability Assessment of Tobacco Products Including Potential Reduced Exposure ProductsCancer Epidemiology, Biomarkers & Prevention, 2009
- Identification of bacterial and fungal components in tobacco and tobacco smokeTobacco Induced Diseases, 2008
- Microbial Community Structure and Dynamics of Dark Fire-Cured Tobacco FermentationApplied and Environmental Microbiology, 2007
- Inflammation and cancerNature, 2002
- Effects of cigarette smoke on the immune systemNature Reviews Immunology, 2002