HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain
Open Access
- 1 September 2013
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Pain
- Vol. 154 (9), 1668-1679
- https://doi.org/10.1016/j.pain.2013.05.021
Abstract
Cess of histone acetylation and are known to have analgesic properties in models of chronic inflammatory pain. The aim of this study was to determine whether these compounds could also affect neuropathic pain. Different class I HDACIs were delivered intrathecally into rat spinal cord in models of traumatic nerve injury and antiretroviral drug–induced peripheral neuropathy (stavudine, d4T). Mechanical and thermal hypersensitivity was attenuated by 40% to 50% as a result of HDACI treatment, but only if started before any insult. The drugs globally increased histone acetylation in the spinal cord, but appeared to have no measurable effects in relevant dorsal root ganglia in this treatment paradigm, suggesting that any potential mechanism should be sought in the central nervous system. Microarray analysis of dorsal cord RNA revealed the signature of the specific compound used (MS-275) and suggested that its main effect was mediated through HDAC1. Taken together, these data support a role for histone acetylation in the emergence of neuropathic pain....This publication has 65 references indexed in Scilit:
- Effects of mitochondrial poisons on the neuropathic pain produced by the chemotherapeutic agents, paclitaxel and oxaliplatinPain, 2012
- Epigenetic suppression of GAD65 expression mediates persistent painNature Medicine, 2011
- Chemical phylogenetics of histone deacetylasesNature Chemical Biology, 2010
- Multiple roles of HDAC inhibition in neurodegenerative conditionsTrends in Neurosciences, 2009
- Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive GenesCell, 2009
- Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRtNature Protocols, 2009
- HDAC2 negatively regulates memory formation and synaptic plasticityNature, 2009
- Comparison of dorsal root ganglion gene expression in rat models of traumatic and HIV‐associated neuropathic painEuropean journal of pain, 2009
- Analyzing real-time PCR data by the comparative CT methodNature Protocols, 2008
- Anticancer activities of histone deacetylase inhibitorsNature Reviews Drug Discovery, 2006