Carboxymethyl Mungbean Starch as a New Pharmaceutical Gelling Agent for Topical Preparation
- 20 October 2008
- journal article
- research article
- Published by Taylor & Francis Ltd in Drug Development and Industrial Pharmacy
- Vol. 35 (1), 34-42
- https://doi.org/10.1080/03639040802144229
Abstract
An application of carboxymethyl mungbean starch (CMMS) as a gelling agent in the topical pharmaceutical preparation was investigated. CMMS was prepared using specific conditions that yielded a high-viscosity product. Polymer gels and gel bases were prepared at 1–10% (wt/wt), and physicochemical studies were carried out in comparison with four standard gelling agents: carbopol 940 (CP), hydroxypropylmethyl cellulose (HPMC), methyl cellulose (MC), and sodium carboxymethyl cellulose (SCMC). Piroxicam was used as a model drug to study the drug release profile of the gel formulations. The tackless, greaseless, and transparent CMMS gels exhibited pseudoplastic behavior with thixotropy at concentrations less than 5% (wt/wt). At a concentration of 5% (wt/wt) and higher, the semisolid gels showed plastic flow characteristics. Viscosity and X-ray diffraction results indicated a good compatibility between CMMS and the acidic piroxicam. No precipitation of piroxicam or phase separation was observed during a stability test. The release rate of piroxicam from 3% (wt/wt) CMMS gel was 1,003.79 ± 105.08 μg/cm2, which was comparable with 947.66 ± 133.70 μg/cm2 obtained from a 0.5% (wt/wt) carbopol formulation. The release profiles of both formulations were consistent and remained unchanged after 2 months' storage. Viscosity played an important role in controlling the release rate of low concentration CMMS formulations by regulating the drug diffusion. At a concentration of 5% (wt/wt) CMMS and higher, the release rates of piroxicam were not significantly different. A plausible explanation based on the nature of the gelling agent was proposed. Stability and drug release profiles of CMMS and commercial gelling agents were compared. The results supported the potential use of CMMS as a new, effective gelling agent for topical gel preparation.Keywords
This publication has 30 references indexed in Scilit:
- Effect of heat treatment of starch on the properties of the starch hydrogelsMaterials Letters, 2008
- Antityrosinase Activity of Some Plant Extracts and Formulations Containing Ellagic AcidPharmaceutical Biology, 2007
- Preparation and Evaluation of Pranoprofen Gel for Percutaneous AdministrationDrug Development and Industrial Pharmacy, 2007
- Synthesis and characterization of biodegradable hydrogels based on starch and succinic anhydrideCarbohydrate Polymers, 2006
- Development of Suspending Agent from Sodium Carboxymethyl Mungbean StarchesDrug Development and Industrial Pharmacy, 2006
- Preparation, in Vitro and in Vivo Evaluation of Liposomal/Niosomal Gel Delivery Systems for ClotrimazoleDrug Development and Industrial Pharmacy, 2005
- Radiation crosslinking of carboxymethyl starchCarbohydrate Polymers, 2004
- Vehicle effects on in vitro release of tiaprofenic acid from different topical formulationsIl Farmaco, 2004
- In vitro release studies of chlorpheniramine maleate from gels prepared by different cellulose derivativesIl Farmaco, 2003
- Influence of aqueous medium on viscoelastic properties of carboxymethylcellulose sodium, hydroxypropyimethyl cellulose, and thermally pre-gelatinized starch gelsColloids and Surfaces A: Physicochemical and Engineering Aspects, 1999