Antityrosinase Activity of Some Plant Extracts and Formulations Containing Ellagic Acid
Open Access
- 1 January 2007
- journal article
- research article
- Published by Taylor & Francis Ltd in Pharmaceutical Biology
- Vol. 45 (6), 519-524
- https://doi.org/10.1080/13880200701446746
Abstract
Ellagic acid (EA) is a naturally occurring polyphenol found in a variety of plants in its free form or in the form of ellagitannin glycosides. In this study, the ellagic acid content of the methanol extracts of Juglans regia. L. (Juglandaceae) leaves, Castanea sativa. Mill. (Fagaceae) stem bark, and Eucalyptus camaldulensis. Dehnh. (Myrtaceae) leaves was determined to develop melanogenesis inhibitors. An improved NaNO2 assay was used for determination of EA. The tyrosinase inhibitory activity of the extracts and synthetic EA was tested in vitro. by monitoring the appearance of dopachrome, an intermediate in the melanogenesis process. The results were compared keeping the same total concentration of inhibitor. The efficacy of EA (1%) was compared with arbutin (1%) and hydroquinone monomethyl ether (1%) as reference substances, and it was found to be a more efficient suppressor of pigmentation. The effect of formulation variables on the tyrosinase inhibitory activity was also evaluated. Based on dopachrome tests performed in the formulations, it could be concluded that the combination with plant extracts had a synergistic effect, and gel formulation could be suggested as an effective carrier for treating uneven skin pigmentation.Keywords
This publication has 15 references indexed in Scilit:
- Skin‐lightening products revisitedInternational Journal of Cosmetic Science, 2003
- Constituents and their antioxidative effects in eucalyptus leaf extract used as a natural food additiveFood Chemistry, 2002
- In vitro and in vivo evaluation of ellagic acid on melanogenesis inhibitionInternational Journal of Cosmetic Science, 2000
- Resveratrol: an original mechanism on tyrosinase inhibitionInternational Journal of Cosmetic Science, 2000
- Quantitative analysis of ellagic acid in hardwood samplesScience of The Total Environment, 1998
- Biological screening of 100 plant extracts for cosmetic use (I): inhibitory activities of tyrosinase and DOPA auto‐oxidationInternational Journal of Cosmetic Science, 1997
- Insoluble ellagitannins in Castanea sativa and Quercus petraea woodsPhytochemistry, 1991
- Quantitative determination of ellagic acidJournal of Agricultural and Food Chemistry, 1990
- Ellagic acidDrugs of the Future, 1986
- Detection and determination of ellagitanninsPhytochemistry, 1972