Is an Automatic Pump Suspension Feature Safe for Children with Type 1 Diabetes? An Exploratory Analysis with a Closed-Loop System
- 1 April 2009
- journal article
- research article
- Published by Mary Ann Liebert Inc in Diabetes Technology & Therapeutics
- Vol. 11 (4), 207-210
- https://doi.org/10.1089/dia.2008.0102
Abstract
Objectives: It has been proposed that the first step towards a closed-loop artificial pancreas might be to use a continuous glucose sensor to automatically suspend the basal insulin delivery based on projected low sensor glucose values. Methods: We reviewed our recent experience with an artificial pancreas system, utilizing a proportional-integrative-derivative (PID) algorithm, in 17 adolescents with type 1 diabetes (T1D) to assess the safety and efficacy of this maneuver. Results: During 34 h of closed-loop automated insulin delivery, 18 pump suspensions ≥60 min (90 ± 18 min) occurred in eight subjects. Sensor glucose levels fell from 159 ± 42 mg/dL to a nadir of 72 ± 13 mg/dL. Corresponding plasma glucose levels fell from 168 ± 51 to 72 ± 16 mg/dL, with values Conclusions: These data suggest that automatic pump suspension using the PID algorithm may be an effective means to prevent hypoglycemia in youth with T1D.Keywords
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