Fully Automated Closed-Loop Insulin Delivery Versus Semiautomated Hybrid Control in Pediatric Patients With Type 1 Diabetes Using an Artificial Pancreas
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Open Access
- 1 May 2008
- journal article
- Published by American Diabetes Association in Diabetes Care
- Vol. 31 (5), 934-939
- https://doi.org/10.2337/dc07-1967
Abstract
OBJECTIVE—The most promising β-cell replacement therapy for children with type 1 diabetes is a closed-loop artificial pancreas incorporating continuous glucose sensors and insulin pumps. The Medtronic MiniMed external physiological insulin delivery (ePID) system combines an external pump and sensor with a variable insulin infusion rate algorithm designed to emulate the physiological characteristics of the β-cell. However, delays in insulin absorption associated with the subcutaneous route of delivery inevitably lead to large postprandial glucose excursions.This publication has 24 references indexed in Scilit:
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